MAPT and Stroke: A National Institute of Neurological Disease and Stroke (NINDS)/National Institute of Biomedical Imaging and Bioengineering (NIBIB) panel defined the pathognomonic lesion of CTE as the perivascular accumulation of hyperphosphorylated tau (p-tau) in neurons and astrocytes in an irregular pattern in the cerebral cortex, most prominent at the depths of the sulci [38].