Expression of oncogenic β-catenin in SOX2 + ve cells of the postnatal pituitary, which contain bona fide organ-specific stem cells results in the initial formation of β-catenin-accumulating cell clusters and subsequent development of ACP-like tumours after a latency period of 3–6 months (Fig. 4a) [43]. This evidence concerns the gene SOX2 and neoplasm.