Karyopherin abnormalities have been implicated in ALS and FTD with TDP-43 pathology,15–20,54 in Alzheimer’s disease and FTD with tau pathology,55–60 in synucleinopathies,61–66 and in cell and animal models of Huntington’s disease,67–70 suggesting karyopherin-associated pathology as a common denominator in the aetiology of neurodegenerative proteinopathies. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.