MAPT and amyotrophic lateral sclerosis: ,75 A common pathological feature found in both diseases are abnormally aggregated cytoplasmic inclusions of TDP-4376,77 that characterize 97% of ALS cases and ∼45% of patients with FTD,71 which are therefore termed FTD-TDP in contrast to FTD cases with tau pathology termed FTD-Tau.