,102 ALS-related mutations in the low complexity region of TDP-43 accelerate the transition of liquid-like droplets to pathologically fibrillized states,8,186 whereas overexpression of KPNA and KPNB1 resulted in reversal and prevention of TDP-43 fibrillization.19 This evidence concerns the gene KPNB1 and amyotrophic lateral sclerosis.