It was demonstrated that SAA might play an important role in the pathogenesis of neurological disorders by up‐regulating the expression of the cytokine interleukin‐1β (IL‐1β), which is mediated by the Nod‐like receptor protein 3 (NLRP3) inflammasome, cathepsin B, and caspase‐1 (Latz et al., 2013). This evidence concerns the gene CTSB and nervous system disorder.