SAA1 and nervous system disorder: It was demonstrated that SAA might play an important role in the pathogenesis of neurological disorders by up‐regulating the expression of the cytokine interleukin‐1β (IL‐1β), which is mediated by the Nod‐like receptor protein 3 (NLRP3) inflammasome, cathepsin B, and caspase‐1 (Latz et al., 2013).