NEDD8 and cancer: Growth of cancer cells is characterized by ordered progression of the cell cycle.[55] MIF coordinates the cell cycle through the association with the Jab1/CSN5 subunit of the COP9/CSN signalosome,[56] which plays a central role in the assembly of SCF complexes by removal of Nedd8 from Cullin.[57, 58, 59] MIF knockout leads to DNA damage and stalled replication.[60] Treatment of A549 cancer cells with the MIF‐directed PROTAC MD13 increased the number of cells in the G2/M phase thus indicating inhibition of cell cycle progression.