Interestingly, combined blockade of the mutually regulated immunosuppressive activities of IL-6 and PD-1/PD-L1 signals enhances expression of T-cell-attracting chemokines and exerts a synergistic antitumor effect, suggesting an IL6-PD1/PD-L1 cross-talk in the tumor microenvironment76. Here, IL6 is linked to neoplasm.