CD44 and neoplasm: Since it is known that Wnt signaling positively regulates tumor progression and osteomimicry in PC47 and that CD44 acts as an inducer of the Wnt-dependent β-catenin signaling pathway31, to identify the possible mechanism underlying CD44v8-10-mediated osteomimetic traits, we examined the constitutive level of Wnt activation in CD44v8-10pos and CD44v8-10neg PC3 cells.