To identify compounds that can effectively inhibit JAK/STAT and NFκB signalling, we constructed a luciferase reporter plasmid which contains both STAT and NFκB‐binding elements (Figure 1A) and stably transfected into human lung cancer cell line A549 to establish the dual target reporter system SKA‐ΙΙ. Here, NFKB1 is linked to lung carcinoma.