Numerous pro‐inflammatory cytokines, such as interleukin 1 (IL1), interleukin 6 (IL6) and tumour necrosis factor α (TNFα), are produced and utilize complex signalling cascades, especially Janus tyrosine kinase/ signal transducer and activator of transcription (JAK/STAT) and nuclear factor kappa B (NFκB) signalling to exert their biological effects in sepsis shock. The gene discussed is IL6; the disease is Sepsis.