Suppressed expression of PGC‐1α results in elevated α‐synuclein oligomerization and enhanced vulnerability of dopaminergic neurons to complex I inhibitors and α‐synuclein toxicity, while its stimulation appeared to improve dopaminergic neuronal viability in PD models and provides neuroprotection against α‐synuclein and neurotoxin‐induced damage7, 9, 36, Xue.41 This evidence concerns the gene PPARGC1A and Parkinson disease.