PPARGC1A and Parkinson disease: Furthermore, since altered expression of miRNAs can profoundly affect PD‐related genes’ expression and disturbed miRNA‐mediated post‐transcriptional regulation is deemed to be an important mechanism in neurodegeneration,20,21 we checked the expression of PGC‐1α/FNDC5/BDNF pathway components as miR‐193b's potential targets in two PD models and PBMCs.