BDNF and Parkinson disease: In agreement with our data showing up‐regulation of BDNF in response to acute MPP+, BDNF levels rose considerably in C57BL6 mice striatum 24 hours after administration of high dose of MPP+, according to Cunha et al.46By contrast, severe suppressed expression of BDNF along with its signalling axis regulator, TrkB, was clearly detected in acute MPTP‐induced PD mice as well.14