Similar to chronic PD model, there was a significant decrease in PGC‐1α, TFAM, FNDC5, TrkB and BDNF expression in PD PBMCs as shown in Figure 5A, while PBMCs of patients with PD showed an increased level of miR‐193b compared with controls (Figure 5B). Here, FNDC5 is linked to Parkinson disease.