In agreement with our data showing up‐regulation of BDNF in response to acute MPP+, BDNF levels rose considerably in C57BL6 mice striatum 24 hours after administration of high dose of MPP+, according to Cunha et al.46By contrast, severe suppressed expression of BDNF along with its signalling axis regulator, TrkB, was clearly detected in acute MPTP‐induced PD mice as well.14 The gene discussed is NTRK2; the disease is Parkinson disease.