LMO3 and obesity due to melanocortin 4 receptor deficiency: Intriguingly and unexpectedly, we found three top-scoring MgSigdb gene sets “TCA cycle,” “Fatty acid metabolism,” and “OX-PHOS” (mitochondrial oxidative phosphorylation), to be enriched specifically in rAAV-Lmo3-transduced eWAT (Fig. 5A and Tables S5), which raises the possibility that LMO3 in eWAT protects against obesity-induced metabolic derangements by increasing mitochondrial functionality in adipocytes.