Ingenuity Pathway Analysis (IPA) software classified these genes into molecular functions implicated in lipid and carbohydrate metabolism/transport being activated (positive Z-score), while molecular features of insulin resistance, dyslipidemia, and hyperglycemia were all suppressed by LMO3 (negative Z-score), respectively (Fig. 1E), and further verified by Q-PCR (Fig. 1F). This evidence concerns the gene LMO3 and Insulin resistance.