In line with these data, using transcriptional profiling as well as biochemical assays in eWAT complemented by LMO3 gain-of-function 3T3-L1 adipocytes, we here show that LMO3 affects mature adipocyte function via PPARγ during obesity based on the following observations: (i) selective enrichment of gene sets implicated with PPARγ activity, (ii) IPA revealed that many of the > 600 LMO3-increased genes in 3T3-L1 adipocytes were predicted to be PPARγ targets, (iii) increased serum levels of adiponectin, and (iv) cell-autonomous increase in adipogenic and PPAR-signaling genes in mature adipocytes. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.