HTRA1 and age-related macular degeneration: Interestingly, only four loci harbored variants that significantly predispose development to the wet subtype: ARMS2-HTRA1 on chromosome 10, CETP on chromosome 16, MMP9 on chromosome 20, and SYN3-TIMP3 on chromosome 22 (mutations in this locus are also associated with Sorby’s Fundus Dystrophy, an AMD-like phenotype).