These risk variants span a ~5-kb region of high linkage disequilibrium (LD) that includes the promoter of HtrA serine peptidase 1 (HTRA1), a secreted serine protease that has been extensively studied for its role in extracellular matrix (ECM) remodeling[120–122], transforming growth factor β (TGF-β) signaling[123–127], and various cancers[128–130]. The gene discussed is HTRA1; the disease is cancer.