However, ARMS2 seems to be an unlikely source for AMD pathogenicity due to (1) its weak expression in the retina[131,132,136,137] and (2) a recent expression quantitative trait loci (eQTL) analysis that found multiple AMD-associated eQTLs that affect HTRA1 expression, but no AMD-associated eQTLs that exclusively affect ARMS2 expression[138]. This evidence concerns the gene HTRA1 and age-related macular degeneration.