The most prominent genetic risk factors for AMD include the nonsynonymous variant rs1061170 on chromosome 1q31, which encodes a Tyr402His substitution in complement factor H (CFH), and an ~5-kb high linkage-disequilibrium (LD) block spanning the age-related maculopathy susceptibility 2/high-temperature requirement A serine peptidase 1 (ARMS2-HTRA1) locus on chromosome 10q26[27–30]. Here, HTRA1 is linked to age-related macular degeneration.