It has been reported that PRR34-AS1 is closely associated with the early tumor recurrence in bile duct cancer (Fang et al., 2020), and it has been proved to potentially relieve ischemic reperfusion injury after total knee arthroplasty in mice by diminishing apoptosis and enhancing cell proliferation of chondrocyte in vitro (Fang et al., 2020). This evidence concerns the gene PRR34 and bile duct cancer.