To decipher the role of CASC9 in CRC growth, proliferation, and migration, we examined the potential pathways related to cell growth, apoptosis, and metastasis and decided to focus on autophagy and EMT (Vellai et al., 2008; Wang and Levine, 2010; Sever and Brugge, 2015; Mathiassen et al., 2017; Brabletz et al., 2018; Pavel et al., 2018; Pastushenko and Blanpain, 2019). This evidence concerns the gene CASC9 and colorectal carcinoma.