PCa-derived exosomal miR-21-5p, miR-100-5p, and miR-139-5p have been reported to upregulate the expression of receptor activator for nuclear factor-κ B ligand (RANKL) and MMP receptor activator in fibroblasts and promote the growth and metastasis of PCa (Sanchez et al., 2016). Here, TNFSF11 is linked to posterior cortical atrophy.