Studies have shown that exosomes derived from LNCaP and DU-145 cells induce PCa cell proliferation, EMT, migration, and IL-8 secretion, and reduce the apoptosis of PCa cells (Waugh and Wilson, 2008; Hosseini-Beheshti et al., 2016; Souza et al., 2018). This evidence concerns the gene CXCL8 and posterior cortical atrophy.