In fact, exosome transfer proteins (e.g., Caveolin-1, PKM2, ITGA3, and ITGB1) from cells with strong invasive ability to weakly invasive cells have been found to increase PCa invasion and metastasis (Bijnsdorp et al., 2013; Hoshino et al., 2015; Dai et al., 2019; Lin et al., 2019). The gene discussed is ITGA3; the disease is posterior cortical atrophy.