While only one paper exists on the significance of WNT5B in osteosarcoma, several highlight the importance of WNT5A. WNT5A was overexpressed in 81% of 42 osteosarcoma immunohistochemistry samples and was significantly correlated with advanced surgical stage and tumor metastasis (Lu et al., 2012). The gene discussed is WNT5A; the disease is neoplasm.