PECAM1 and neoplasm: Additionally, angiogenesis was dramatically reduced by LM8-SEV suppression, as indicated by a 75% reduction in CD31-positive vessels (Figures 1C, D) and an approximate 75% reduction in VEGF-positive areas (Figures 1E, F) in mice bearing TSG101-KO cells, possibly contributing to the slow tumor growth of TSG101-KO cells.