INS and diabetes mellitus: This is in agreement with a large-scale study conducted by Aoyama-Sasabe et al., in the Japanese population, where they have observed, a reduction in early-phase insulin secretion as the most important factor responsible for elevation of two-hour glucose levels during OGTT in isolated IGT subjects [27]. Restoration of first-phase insulin secretion by dietary and therapeutic means has been proposed as a method not only for the prevention of diabetes but also for the prevention of cardiovascular events [28].