According to a study in obese youth by Yeckel et al., insulin secretion as measured by the insulinogenic index has a strong impact on postprandial glucose levels even within the normal range, and in all insulin sensitivity tertiles [7]. Studies have suggested that reduced β-cell function manifested as reduced insulin release is a prerequisite for the progression from normal glucose tolerance (NGT) to hyperglycemia [8]. Here, INS is linked to Hyperglycemia.