PHF2 and cancer: Suppression of H3K9me2/me3 demethylase activity such as KDM3A (JMJD1A), KDM4C (JMJD2C), and KDM7C (PHF2) in tissue specific stem cell cultures and cancer cells can lead to premature senescence, increased DNA damage and genomic instability (Huang et al., 2019; Pappa et al., 2019; Fan et al., 2020).