SETD2 and lung cancer: Hypoxic mouse stromal cells are shown to be more resistant to irradiation than the same cells under normoxic conditions in a HIF-1 dependent manner (Calvo-Asensio et al., 2018), and a lung cancer model expressing a HIF-1-stabilizing micro RNA exhibits a hypoxic phenotype and increased radioresistance (Grosso et al., 2013).