KDM5C and hereditary clear cell renal cell carcinoma: Demethylation of H3K4me3 by KDM5C (JARID1C) leads to heterochromatin formation, and renal cell carcinoma patients with JARID1C mutations exhibit genome-wide DNA hypomethylation, increased genomic rearrangements, and an overall worse prognosis (Rondinelli et al., 2015).