MYC and cancer: While c-Myc DNA hypomethylation is observed in many different cancers, other examples of hypomethylated oncogenic loci are cancer-specific, such as the melanoma-associated antigens (MAGE) gene that is hypomethylated specifically in gastric cancer and colorectal cancer (Honda et al., 2004; Kim et al., 2006) or synuclein γ (SNCG) in breast and ovarian cancers and solid tumors of the liver, gastric and (Gupta et al., 2003; Liu et al., 2005).