Svct2 knockout in bone marrow cells expressing the AML oncogene Flt3ITD has also been shown to accelerate leukemia progression in mice and exacerbate 5hmC loss in Tet2 deficient HSCs, suggesting that vitamin C depletion could further impair the activity of other TET proteins in pre-leukemic cells (Agathocleous et al., 2017). Here, TET2 is linked to acute myeloid leukemia.