Furthermore, the prevalence of DNMT3A and TET2 mutation in hematological malignancies, and their early emergence from within the HSPC compartment to drive transformation (Delhommeau et al., 2009; Quivoron et al., 2011; Welch et al., 2012; Papaemmanuil et al., 2013), emphasizes the importance of DNA methylation in the pre-malignant regulation of stem cell self-renewal and blood cell lineage differentiation. This evidence concerns the gene TET2 and hematologic disorder.