In lung diseases such as chronic obstructive pulmonary disease (COPD) (a progressive inflammatory lung disorder characterized by shortness of breath and coughing), hypersensitivity pneumonitis (rare immune system disorder affecting resulting in hypersensitivity to inhaled dust) and allergic asthma (resulting from exposure to allergens e.g. pollen), roles for GrA and GrB have been reported. The gene discussed is GZMB; the disease is chronic obstructive pulmonary disease.