In a murine model of periodontal bone loss infected with Porphyromonas gingivalis and an in vitro study in MOLC MC3T3-E1 treated with LPS from P. gingivalis the inhibition of GSK3β with SB216763 before infection or LPS stimulation, induced the inhibition of the pro inflammatory cytokines IL-12p40, TNF-α, IL-1β, IL-6, and IL-17 expression (44, 45) (Table S1). The gene discussed is GSK3B; the disease is infection.