During viral infection, activation of GSK3β by TLR3/TRIF signaling pathway controls the tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6)-mitogen-activated protein kinase mitogen activated protein kinase kinase kinase (MAP3K7)-(TAK1) and receptor-interacting serine/threonine-protein 1(RIP1)/NF-κB axis to positively regulate pro-inflammatory cytokine production. This evidence concerns the gene GSK3B and viral infectious disease.