GSK3β-siRNA knockdown diminished expression of TNF-α in LPS(UO)-stimulated RAW 264.7 macrophages (50), inhibited NF-κB activation, enhanced CREB activation in LPS(UO)-stimulated acute monocytic leukemia THP-1 cells (95), and diminished expression of IL-1β, IL-6, and TNF-α in WNV infected HGC U251 cells (96). Here, TNF is linked to acute monocytic leukemia.