In order to update and discuss the most recent data published on modulation of the inflammatory response by GSK3β we searched for articles from 2012-2021 in the PubMed database that contained one of the following combination of keywords: GSK3beta inflammation bacterial infections (12 articles), GSK3beta inflammation lipopolysaccharide (104 articles), GSK3beta inflammation peptidoglycan (PGN) (6 articles), GSK3beta inflammation virus infection (25 articles), GSK3beta inflammation parasites infection (6 articles). The gene discussed is GSK3B; the disease is bacterial infectious disease.