In an animal model of keratitis it was observed that infection of corneal cells with Pseudomonas aeruginosa promoted GSK3β activation by decreasing its phosphorylation at Ser9, while the inhibition of GSK3β with SB216763, before P. aeruginosa infection, reduced the cornea inflammation by reducing the expression of IL-6 and IL-1β and by reducing the bacterial load (22). This evidence concerns the gene IL1B and infection.