In the context of viral infection, human hepatic CSCs (Huh7, JFH-1-Huh7, Huh7.5, and MH14C) treated with BIO and infected with HCV suffered an impairment of IFN signaling via inhibition of signal transducer and activator of transcription 1 (STAT1) phosphorylation and degradation (51). This evidence concerns the gene STAT1 and viral infectious disease.