However, another group reported that low-dose Deci (0.2 mg/kg) reduces the antitumor response of NK cells in tumor-bearing mice (75), and Deci has also been shown to increase the cell surface expression of recombinant UL16 binding protein (ULBP) (62) and MHC class I-related molecule B (MICB) (63), the ligands of NKG2D in AML cells, and the NKG2D-dependent sensitivity of these cells to NK-mediated killing in vitro. This evidence concerns the gene KLRK1 and acute myeloid leukemia.