The most prominent perturbations centered on the repression of those genes governing mitochondrial biogenesis (TFAM), mitochondrial OXPHOS (OXA1L, NDUFB6, ETFB, LRPPRC, SDHB, COX5B, NDUFA9, NDUFA2, MRPS12, PDHB, NDUFB4, VDAC1), oxidative defense (GPX6, SOD1, GPX7), glycolysis (ALDOA, HK1, ADH5, PDHA1, ALDH3B1), gluconeogenesis (GYS2), fatty acid and cholesterol synthesis (HMGS1, EHHADH, DGAT1, HADH, HACD3, HADHA, ACSM3, ADADSB, PPT1, ACSBG1), β-oxidation (CPT1C, CPT2, ACADM), lactate transportation (SLC16A10), and nucleotide metabolism (ADCY7) during HIV infection. The gene discussed is HK1; the disease is HIV infectious disease.