CD40LG and Waldenstrom macroglobulinemia: Waldenström’s macroglobulinemia (WM) is an incurable indolent B-cell lymphoma of the elderly accounting for less than 5% of B-cell lymphomas with, as unique characteristics, a serum IgM peak and primary medullary localization of lymphoplasmacytic cells that exhibit continuous differentiation from mature B lymphocytes to IgM secretory plasma cells (1).