Postprandial hyperglycemia should be treated with rapid analogue at initial dosage of 0.05 to 0.1 UI/kg before meal or an insulin/carbohydrate ratio starting with 1UI: 15 g and 1UI: 30 g ratio and subsequently modified on the basis of different intakes of the day and of the degree of insulin resistance at each moment. This evidence concerns the gene INS and Hyperglycemia.