ADRB3 and obesity due to melanocortin 4 receptor deficiency: Meanwhile, thermogenic stimuli such as cold exposure and β3-AR agonists treatment, have been reported to protect against metabolic derangements in obesity partially via triggering anti-inflammatory responses during tissue remodeling and beige adipogenesis (Lee et al., 2013; Hui et al., 2015; Burl et al., 2018).