In the present study, via analyzing the transcriptomics of chronic cold exposure or CL administration, we revealed the commonalities and heterogeneity of these two powerful instigators of white fat browning, which may provide novel insights into the theoretical basis in order to optimize β3-AR agonists for the treatment of obesity and metabolic diseases. The gene discussed is ADRB3; the disease is obesity due to melanocortin 4 receptor deficiency.