ADRB3 and overactive bladder: Besides, previous studies have shown that β3-AR stimulation with sympathomimetic ephedrine had no thermogenic effect on human BAT, while mirabegron, a β3-AR agonist used to treat an overactive bladder, was effective in activating BAT as compared to placebo but may have adverse impacts on glucose homeostasis (Cypess et al., 2012, 2015).