CFD and polycystic ovary syndrome: Clinical evidences indicated that circulating adipsin were positively associated with adiposity, polycystic ovary syndrome (PCOS), insulin resistance (IR), and the development of coronary artery disease (Derosa et al., 2013; Gursoy Calan et al., 2016; Guo et al., 2019; Ohtsuki et al., 2019).