Congruent with our previous reports (Mijares et al., 2014), we have confirmed that the lack of dystrophin in mdx cardiomyocytes with proven cardiomyopathy causes an age-dependent [Ca2+]d and [Na+]d overload (15-month > 12-month > 3-month) compared with age-matched WT cardiomyocytes. Here, DMD is linked to cardiomyopathy.