This study we tested the hypothesis that WBPA can ameliorate or reverse the severity of cardiomyopathy in dystrophin-deficient mdx mice by reducing diastolic [Ca2+] and [Na+] and oxidative stress and upregulating utrophin expression, which leads to a reduction in cardiomyocytes damage, increased cell viability, and improved cardiomyocyte contractility. This evidence concerns the gene UTRN and cardiomyopathy.