Some hypotheses suggest that sepsis is associated with an early overwhelming innate immune response, characterized by dysregulation of the overproduction of cytokines (TNF-α, IL-1β, IL-6, IL-8) (Benjamim et al., 2004; Faix, 2013; Chousterman et al., 2017). The gene discussed is CXCL8; the disease is Sepsis.