Similarly, IFN-α/β receptor (IFNAR)-deficient mice are highly susceptible to ZIKV infection (Lazear et al., 2016), and IFN-α considerately inhibits ZIKV infection in vitro alone or in combination with favipiravir (Pires de Mello et al., 2018b). Here, IFNA2 is linked to Zika virus infectious disease.