CHRNA7 and acute lung injury: This line of reasoning is supported by the documented involvement of cholinergic signaling through α7nAChR-mediated mechanisms in the inflammatory reflex (Wang et al., 2003; de Jonge and Ulloa, 2007) and the anti-inflammatory therapeutic efficacy of VNS and α7nAChR agonists in models of acute lung injury (Su et al., 2007; dos Santos et al., 2011; Sitapara et al., 2020).