SLC8A1 and brain ischemia: The ways of calcium entering neurons following cerebral ischemia include glutamate receptors; voltage-dependent calcium channel; transient receptor potential channels; acid-sensing ion channels; sodium-calcium exchanger operating in entry mode; inward excitotoxic injury current calcium permeable channels; mitochondria and endoplasmic reticulum calcium release, etc. And the pathways of calcium exit into neurons include Ca2+-ATPase pump; Na+-Ca2+ exchanger operating in exit mode, etc (Singh et al., 2019).