On the other hand, CBS can also be related to the spectrum of other neuropathologies such as AD, PSP, Pick’s disease (PiD), fronto-temporal lobar degeneration with ubiquitin–TDP-43-positive inclusions (FTLD-TDP), Lewy body disease (LBD), and Creutzfeldt–Jakob disease (CJD) and globular glial tauopathy (Boeve, 2011; Parmera et al., 2016; Marsili et al., 2018). This evidence concerns the gene CBS and Alzheimer disease.