Jin et al. (2000) proved that VEGF may protect neurons from hypoxic or ischemic injury. The results of the study by Borroni, support a role for specific VEGF polymorphisms and haplotypes as risk factors for neurodegenerative diseases. Also, this study suggests the key role of genetic background in CBS pathogenesis proving that AGG (-2578C/A, -1190G/A, -1154G/A) haplotype carriers had a 6-fold increased risk to develop CBS than non-carriers. These data suggest that specific genetic variations of VEGF are a predisposing risk factor for CBS (Borroni et al., 2010). Here, CBS is linked to neurodegenerative disease.