However, in iCCA FMRP was detected (Fig. 1a, left panel, T region) with an expression level ranging from low (IHC score = 1) to high (IHC score = 2) (Fig. 1b, c), and with an overall significant overexpression in the tumor tissues, compared to non-neoplastic bile ducts (Fig. 1c, left panel). This evidence concerns the gene FMR1 and neoplasm.