FMR1 and neoplasm: About the molecular mechanism by which FMRP could have such a pathogenetic effect, we observed that it is particularly enriched in the cells localized at the tumor-host interface (named “invasive tumor front” ITF) [38], with a peculiar intracellular dotted and under-membrane localization which resembles the neuronal pattern [39] and which suggests a common function for FMRP in all polarized cells: the local regulation of mRNA metabolism (localization, stability, and local protein synthesis) at the leading edge.