FMR1 and pancreatic neuroendocrine tumor: In particular, FMR1 gene, encoding for FMRP, is overexpressed in both pre-neoplastic and neoplastic stages of HCC [20, 21] and was identified as a metastasis-related gene in an HCC cell line derived from lung metastatic lesions [22], as well as a downstream effector of NMDAR signaling pathway that influences invasive tumor growth in a mouse model of pancreatic neuroendocrine tumor (PanNET) [23].