Many of the proteins presented in Fig. 3 have been previously associated with Alzheimer’s disease phenotype and include enzymes (e.g. monoamine oxidases—MAO A and B, Amiloride-sensitive amine oxidase AOC1, 2 and 3, Carnitine Palmitoyltransferase—CPT1A,B and C) as well as number of transporters including SLC22A1, 4, 5 and 9; SLC2520 and 29. This evidence concerns the gene AOC1 and early-onset autosomal dominant Alzheimer disease.