TNF and metabolic syndrome: We used Weighted Gene Correlation Network Analysis (WGCNA) and found several modules of co-expressed genes showing significant correlation with intermediate traits of T2D and metabolic syndrome such as TNFα, hsCRP, Serum Creatinine, IL6, NEFA, VLDL, LDL, HDL, blood glucose, Hb1Ac, adipocyte size, insulin, HOMA-B, HOMA-IR, leptin, adiponectin etc. These results strengthen the belief that it is indeed the sick fat or adiposopathy, which is the root cause of metabolic syndrome and diabetes and affects both—peripheral, as well as visceral adipose tissue compartments6.