As lipodystrophy is a monogenic disorder with Mendelian mode of transmission, whereas T2D is a complex multifactorial disease and its clinical picture is created by the interaction of several environmental and genetic factors such as frequent polymorphisms of multiple genes, still both exhibit similar pathophysiological alteration such as heightened insulin resistance, loss of peripheral fat, ectopic fat deposition, and adipocytokinemia etc. Presence of these genes therefore points toward the fact that thin fat phenotype might be a functional variant of lipodystrophy. This evidence concerns the gene INS and lipodystrophy.