Subsequently, reduced “m6A-YTHDF2” signaling promoted the expression and stability of critical tumor oncogenes, such as SOX2, SMAD7, and MYC. Our study indicates that LKB1 loss reduces m6A modification by upregulating ALKBH5, which contributes to aggressive tumor progression and poorer outcomes for KL lung cancer. This evidence concerns the gene SMAD7 and lung cancer.