The absence of Emx1 or Emx2 increased inflammation in the 3MC-induced sarcomas (Supplementary Fig. FS4); we observed that all induced tumors in all genotypes showed similar KI67 immunostaining levels (60–65 ± 12%) compared to 8–9 ± 2% in non-tumoral tissue sections. Here, EMX2 is linked to sarcoma.