LSD1 binds to the methylated lysine in the 8KSKK11 motif in the SNAG (Snail/GFI1) domain, and thereby helps recruit RCOR1-HDAC1/2 co-repressor complex to mediate transcriptional repression and differentiation block due to GFI1 activity in AML stem/progenitor cells19–22. This evidence concerns the gene GFI1 and acute myeloid leukemia.