Since effects of LSD1-KD (utilizing shRNA) or LSD1-KO (via CRISPR-Cas9) on epigenome/transcriptome can only be evaluated several days after gene-editing, we next determined whether these effects also occur soon after a 16-h exposure of AML and post-MPN sAML cells to INCB. The gene discussed is KDM1A; the disease is acute myeloid leukemia.