SPI1 and myeloproliferative disorder: Studies presented here also involved CRISPR-Cas9-mediated KO of LSD1 or shRNA-mediated KD of LSD1, which showed induction of GFI1/1B, as well as of PU.1, CEBPα, and p21, but repression of c-Myc in both post-MPN-sAML and non-MPN associated AML cells.