Additionally, as shown in Fig. 5I, in a short-term in vitro culture of PD, post-MPN sAML progenitor cells (sAML#20), LSD1-KO via CRISPR-Cas9 significantly enhanced ruxolitinib-induced lethality (p < 0.01). This evidence concerns the gene KDM1A and myeloproliferative neoplasm.