In present studies, utilizing for the first time CRISPR-Cas9, or LSD1-FKBP12F36V and dTAG-13, we demonstrate that knockout (KO) or degradation of LSD1 inhibits growth and induces differentiation of AML BPCs with or without expression of MLL fusion oncoproteins, and of post-MPN sAML BPCs. The gene discussed is KMT2A; the disease is acute myeloid leukemia.