For example, in the pancreas, the activation of the NPY receptor can reduce β-cell apoptosis and hyperglycemia.216 The role of NPY in adipose tissue is to promote adipocyte proliferation and adipogenesis.214 This suggests that in addition to its secretion in the brain, NPY secreted by peripheral tissues also has profound regulatory functions in the endocrine system.217,218. Here, NPY is linked to Hyperglycemia.