Therefore, the decrease in insulin absorption by bone may lead to systemic insulin resistance, which proves the influence of insulin and bone on whole-body energy metabolism from another aspect.306 On the other hand, insulin resistance in osteoblasts leads to decreased circulating osteocalcin levels, reducing insulin secretion and insulin sensitivity in skeletal muscle, thus leading to systemic glucose intolerance.307,308. The gene discussed is INS; the disease is Insulin resistance.