Further studies showed that the SIRT1 gene serves as the downstream target of miR-29b-3p regulating insulin sensitivity, and miR-2 9b-3p can directly conjugate to the SIRT1 gene and suppress its expression.250 In addition, because exosomes contain immunoregulatory factors, they also play a role in repairing liver fibrosis, including reducing collagen accumulation, enhancing liver function, inhibiting inflammation, and promoting liver cell regeneration.251 Cytologically, exosomes contain various bioactive substances, which make them attractive potential therapeutic sources. This evidence concerns the gene SIRT1 and Hepatic fibrosis.