For example, OPG has been found to be a potential marker for the diagnosis of diabetes in postmenopausal women,358 and experiments have explored whether regulating the proportion of OPG-RANKL-RANK signaling can interfere with the process of cardiovascular complications noted in patients with diabetes.359 More experiments are needed to further apply bone-derived factors to the treatment of clinical diseases. This evidence concerns the gene TNFSF11 and diabetes mellitus.