Accordingly, shRNA-mediated knockdown of circSlc8a1 exerted protective effects against cardiac hypertrophy in vivo.98 Finally, circ_Lrp6 expression was elevated in mouse and human vascular smooth muscle cells (VSMC) and acted as a sponge for miR-145.99 Circ_Lrp6 shRNA suppressed VSMC proliferation and migration in vitro and reduced intimal hyperplasia in the carotid arteries of a mouse model of stenosis. Here, LRP6 is linked to cardiac hypertrophy.