CircNfix was highly expressed in adult cardiomyocytes in mice, rats, and humans but was initially downregulated in mice post-myocardial infarction (MI).92 This circRNA was reported to sponge miR-214 and upregulate Gsk3β, and also facilitate the interaction between Ybx1 and E3 ubiquitin-protein ligase Nedd4I. The gene discussed is UBE2E3; the disease is myocardial infarction.