DNMT3B and cardiomyopathy: Silencing circFoxo3 through siRNA inhibited senescence and attenuated Doxorubicin (Dox)-induced cardiomyopathy.62 In addition, ACR circRNA expression was significantly downregulated in mouse heart tissues after ischemia/reperfusion (I/R) injury.97 ACR sequestered Dnmt3B to prevent Dnmt3B-induced methylation of the Pink1 promoter.