CircFoxo3 was shown to bind several proteins, ID-1, E2F1, HIF1α, and FAK that exert protective effects against cardiac senescence, promoting their retention in the cytoplasm and suppressing their downstream activity.62 In contrast, circAmotl1 facilitated the nuclear translocation of several proteins: c-myc, an oncogenic transcription factor,63 protein kinase B/AKT, which protected against cardiomyopathy,13 and STAT3, a transcription factor that contributed to skin wound repair,14 ultimately promoting their respective functions. This evidence concerns the gene AKT1 and cardiomyopathy.