NLRP3 and major depressive disorder: A more recent study on the role of circHIPK2 in depression showed transplantation of gut microbiota from NLRP3 KO mice alleviated astrocyte dysfunction and depression-like behavior induced by chronic unpredictable stress through inhibition of circHIPK2.111 Delivering siRNA targeting circHIPK2 into the hippocampus recovered astrocyte dysfunction and attenuated depression-like behavior.