TIPARP and androgen insensitivity syndrome: CircHECTD1 was significantly upregulated in the plasma of acute ischemic stroke (AIS) patients and in a transient middle cerebral artery occlusion (tMCAO) mouse stroke model.104 CircHECTD1 sponged miR-142 to upregulate TIPARP and inhibited astrocyte activation via autophagy.