STAT1 and alkaline phosphatase measurement: It has been reported previously that acute alcohol intake activates STAT1/3 pathways and concomitantly induces the STAT3-inhibiting suppressors of cytokine signaling in monocytes, leading to down-regulation of IL-6–induced STAT1/STAT3 signaling.26 This seems compatible with our finding that IL-6–stimulated pSTAT1 levels of monocytes and T cells of patients with AP are low.