To clarify the immune function of CD45RO+CD8+ T lymphocytes and CD45RA+CD8+ T lymphocytes, we injected 1 × 108 CD45RO+CD8+ T lymphocytes or CD45RO+CD8+ T lymphocytes per week after ccRCC model was successfully established. This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.