And it has been reported that, in Hodgkin Lymphoma, the galectin-1 has been illustrated to modulate immune suppressive functionality of CD8+ T lymphocytes, which could support the speculation that the RO/RA ratio descending in patients loading cancer might be ignited by at least the galectin-1 expressed by tumor cells with CD45RO+ T cells eventually sinking into apoptosis yet CD45RA+ T cells [27]. Here, CD8A is linked to neoplasm.