We hypothesized that epigenetic modifiers could be downstream effectors of MYCN and attractive drug targets to restore IFN responsiveness and chemokine expression in NBs.30 We therefore analyzed transcriptome data of a well-characterized cohort of INSS stage 4 NBs (metastatic disease) and we ranked genes based on their correlation with the IFN-γ-responsive chemokine CXCL10. 31 Of note, one of the most negatively correlated gene encoded for the euchromatic histone lysine methyltransferase 2 (EHMT2), also known as G9a (figure 1A and online supplemental figure 1A, B). Here, CXCL10 is linked to metastatic neoplasm.