Even though our re-analysis of public ChIP-seq data indicated binding of MYC to the regulatory regions of EHMT2 and EZH2, less total MYC versus MYCN and/or functional differences between MYC and MYCN may explain higher expression and dependence on EHMT2 and EZH2 activity in MYCN-amplified NB cell lines. Here, EZH2 is linked to neuroblastoma.