MYCN-non-amplified SH-SY5Y cells expressed high levels of MYC (online supplemental figure 1C) and showed the strongest antiproliferative response to EHMT inhibitors among the MYCN-non-amplified NB cell lines tested (figure 3A–D), for which reason SH-SY5Y cells were also a valuable model. The gene discussed is MYCN; the disease is neuroblastoma.