Analysis of the CCLE data set showed that EHMT2 and EHMT1 mRNA expression was significantly higher in NB cells when compared with other cell lines from various types of cancers, which indicated potential lineage-specific functions of EHMTs (figure 1J, K).29 Altogether, our correlation analyses suggested a potential role for EHMT2 and EHMT1 in the repression of IFN-γ-responsive chemokines like CXCL10 in NB cells, whereby MYCN and possibly also high levels of MYC directly promote EHMT2 expression together with EZH2. This evidence concerns the gene IFNG and neuroblastoma.