EZH2 and Nijmegen breakage syndrome: Therefore, our study provides a scientific basis to explore EHMT inhibitors, alone (maybe in a subset of MYCN-non-amplified NBs) or in combination with EZH2 inhibitors (in particular MYCN-amplified NBs), for targeted immunomodulation of NBs to induce a ‘hot’ TME phenotype for improved responsiveness to ICB therapy.