Recently, MYC was found to directly interact with EHMTs mediating gene repression and promoting tumorigenesis.38 At least in the case of regulation of CXCL9, CXCL10 and CXCL11 expression in NB cells, neither MYCN nor MYC seemed to be directly involved in the recruitment of the EHMT/EZH2 repressive complexes, but indirectly by increasing the levels of EHMT2 and EZH2 in NB cells. This evidence concerns the gene MYC and neuroblastoma.