EZH2 and neuroblastoma: Of note, PRC2 physically interacts with the EHMT (G9a/GLP) complex and functionally cooperates in transcriptional repression.33 Thus, GSEA suggested to combine PRC2 inhibitors (eg, EZH2 inhibitors) with EHMT inhibitors in order to achieve robust transcriptional responses to IFN-γ also in MYCN-amplified NB cells.