CGAS and neuroblastoma: We previously proposed that STING agonists could be promising drugs to induce conversion of ‘cold’ to ‘hot’ TMEs in NB.12 The cGAS/STING pathway plays a central role in the sensing of cytosolic DNA and its activation triggers a strong type I IFN response.19 Recently, Wang-Bishop et al20 demonstrated that intratumoral application of STING-activating nanoparticles induced immunogenic cell death, chemokine release and a T-cell-inflamed ‘hot’ TME in transplantable mouse models of NB improving ICB therapy.