Interestingly, EHMT inhibition enhanced IFN-γ-induced expression of CXCL10 and interferon responsive genes (MSigDb Hallmark IFN-γ response) to a larger extent in MYCN-non-amplified than in MYCN-amplified NB cell lines (figure 3E, F). The gene discussed is CXCL10; the disease is neuroblastoma.