CX3CL1 and neoplasm: Another group of GSs significantly enriched in tumors of women, were related to leukocyte cell-cell adhesion and migration, and indeed we found that TME of women was characterized by significantly higher expression levels of a number of chemokines, receptors and integrins specifically known to play a key role in leukocytes extravasation and tumor infiltration, including: CCL5, CX3CL1, CXCL9, BTN3A2, ICAM1 and LFA1 (FDR≤0.05 for each with exception of CXCL9 for which FDR was 0.06 supplementary fig.