Since we found that tumors of men had impaired neoantigens presentation mechanisms as compared with women, we analyzed data of the cohort of 329 patients from MSKCC dataset, with advanced NSCLC and treated with anti-PD-1 or anti-PD-L1 as monotherapy, to test the hypothesis of sex-based differences in the association between tTMB and patients outcome.10–11. Here, CD274 is linked to non-small cell lung carcinoma.