HLA-C and cancer: Another mechanism underlying the lower immune infiltration of tumors of men, was the higher degree of hypoxia in TME, that has been reported to impair infiltration and proliferation of immune cells.33,34,36 Furthermore, the oxidative metabolic state of cancer cells directly affects antigen presentations mechanisms: it has been demonstrated that tumors characterized by higher glycolysis/OXPHOS ratio had significantly lower expression of multiple members of the antigen processing and presentation machinery, including MHC molecules.37,38