According to recent studies, genetic polymorphisms in the ACE2 gene were detected in populations, which modulate the SARS-CoV-2 affinity spike protein and worsen pulmonary and systemic injury by accelerating lung damage in COVID-19 patients, which enhanced vasoconstriction, inflammation, oxidation, coagulation, capillary permeability, fibrosis, and apoptosis in the alveolar cells [37, 60]. The gene discussed is ACE2; the disease is COVID-19.