One of the reasons for the difference in genetic susceptibility to COVID-19 on one hand, and risk factors like high-risk male patients with cancer, on the other hand, can be the presence of a high number of polymorphisms in TMPRSS2 [e.g., p.Val160Met (rs12329760) which is an expression quantitative trait locus (eQTL)]. This evidence concerns the gene TMPRSS2 and COVID-19.