Moreover, based on studies reporting that patients with severe asthma have diminished GCs sensitivity in peripheral blood monocytes (PBMCs) in comparison with patients with nonsevere asthma, in association with decreased HDAC2 activity that parallels the impairment in GCs sensitivity [34], we analyzed HDAC2 activity with an HDAC2 activity assay kit. This evidence concerns the gene HDAC2 and asthma.