Identification of patients that are at high risk of progression to advanced clinical stages needing treatment in chronic lymphocytic leukemia (CLL) is expedited by the use of different prognostic parameters including the mutational status of the IGHV genes or its surrogates like ZAP-70 expression [1, 2], chromosomal aberrations and gene mutations (i.e., TP53 or NOTCH1), [3, 4] or prognostic scores like the CLL-IPI [5]. This evidence concerns the gene NOTCH1 and B-cell chronic lymphocytic leukemia.