In this regard, Gonnord et al. recently described that CD8+ T cells from untreated CLL patients that will need therapy within 6 months after analysis display an unique signature which is not correlated with the time that CD8+ T cells have been exposed to CLL cells [52], indicating again that the exhaustion of T cells is not a mere product of increased exposure to malignant cells, either in time or in tumoral load. The gene discussed is CD8A; the disease is B-cell chronic lymphocytic leukemia.