MED25 was previously shown to play a critical role in the endoplasmic reticulum stress response [69] Here, a number of the DEPs identified in the current work, including TSPAN8, SUMO3, INSL3, and MED25, were implicated in obesity-related infertility or subfertility. Here, MED25 is linked to obesity due to melanocortin 4 receptor deficiency.