Systematic reviews [20, 21] seem to conclude that AI may have a place in endometriosis treatment, but there is no clear evidence of improvement in endometriosis-associated infertility [22]; and the Committee Opinion No. 663 on Aromatase Inhibitors in gynecologic practice [23] pointed that AI are a promising therapeutic option that may be useful for the management of endometriosis-associated pain in combined therapy with progestins. The gene discussed is CYP19A1; the disease is endometriosis.