According to Oncomine, PDE9A was discovered to be downregulated in various colorectal cancer including Colorectal Adenoma, Rectal Mucinous Adenocarcinoma, Cecum Adenocarcinoma, Colon Adenoma, Rectal Adenocarcinoma, Colorectal Carcinoma, Colon Mucinous Adenocarcinoma, Colon Adenocarcinoma, Colon Carcinoma (Fig. 2, Table 1). This evidence concerns the gene PDE9A and colon adenocarcinoma.