PDE9A and malignant colon neoplasm: We used different databases namely Gent2 (Fig. 8), PrognoScan (Fig. 9, supplementary Table 3), GEPIA (Fig. 10), UALCAN (Supplementary Fig. 4), OncoLnc (Supplementary Fig. 4), and R2 (Supplementary Fig. 4) to analyze the survival plot or Kaplan-Meier plot for the PDE9A gene against colon cancer.