PDE9A expression was downregulated in various colorectal cancer types including Colorectal Adenoma, Colon Mucinous Adenocarcinoma, Colon Adenocarcinoma, Colon Adenoma, Colon Carcinoma, Colorectal Carcinoma, etc. (Fig. 2 and Table 1). Here, PDE9A is linked to colorectal adenoma.