TMPRSS2 and obesity due to melanocortin 4 receptor deficiency: g. Angiotensin-converting enzyme 2 [ACE2] and transmembrane protease serine 2 [TMPRSS2]) [33, 34], (iii) heritage and ethnicity [35], (iv) the presence of comorbidities (hypertension, diabetes, obesity, and immunological diseases) [36, 37] were already associated to increased disease severity, although more integrative studies are still needed to identify the relative contribution of each of these factors.