g. Angiotensin-converting enzyme 2 [ACE2] and transmembrane protease serine 2 [TMPRSS2]) [33, 34], (iii) heritage and ethnicity [35], (iv) the presence of comorbidities (hypertension, diabetes, obesity, and immunological diseases) [36, 37] were already associated to increased disease severity, although more integrative studies are still needed to identify the relative contribution of each of these factors. Here, ACE2 is linked to obesity due to melanocortin 4 receptor deficiency.